which issue is related to long - term marijuana use?\n○ brain damage\n○ difficulty thinking\n○ mood…

Brief Explanations:

Long - term marijuana use can affect cognitive functions. It can lead to difficulty in thinking due to its impact on the brain's neural pathways and neurotransmitter systems. While brain damage is less common as a direct result, difficulty thinking is a well - documented consequence. Mood swings can be a short - term effect and altered senses are more immediate effects rather than long - term ones.

Answer:

difficulty thinking