which issue is related to long - term marijuana use?\nbrain damage\ndifficulty thinking\nmood…

Brief Explanations:

Long - term marijuana use can affect cognitive functions. Difficulty thinking is a common long - term effect due to the impact on the brain's neural pathways and neurotransmitter systems. Brain damage is an extreme and less common long - term effect compared to difficulty thinking. Mood swings and altered senses are more short - term effects.

Answer:

difficulty thinking