which type of mutation causes sickle cell anemia?\no silent\no missense\no insertion\no frameshift

Brief Explanations:

Sickle - cell anemia is caused by a single - base substitution where a glutamic acid (Glu) is replaced by valine (Val) at the sixth position of the beta - globin chain. This is a missense mutation as it changes the amino - acid sequence of the protein. A silent mutation would not change the amino - acid sequence, an insertion adds nucleotides, and a frameshift mutation is due to insertions or deletions that shift the reading frame.

Answer:

missense