which type of mutation causes sickle cell anemia?\n○ silent\n○ missense\n○ insertion\n○ frameshift
which type of mutation causes sickle cell anemia?\n○ silent\n○ missense\n○ insertion\n○ frameshift
Answer
Brief Explanations:
Sickle cell anemia is caused by a specific type of point mutation in the gene that codes for the beta-globin chain of hemoglobin. This mutation involves a single nucleotide change (specifically, an adenine is replaced by a thymine in the DNA template strand). This change alters the corresponding mRNA codon from GAG (coding for glutamic acid) to GUG (coding for valine). As a result, the sixth amino acid in the beta-globin chain is changed from glutamic acid to valine. A mutation that changes a single nucleotide and results in the substitution of one amino acid for another is classified as a missense mutation. The image provided illustrates this change, showing Glutamic acid (Glu) at position 6 in the normal sequence and Valine (Val) at position 6 in the mutated sequence associated with sickle cell anemia.
Answer:
missense